Abstract
Currently, there is no effective means to evaluate donepezil response. We evaluated brain perfusion change at 4h after donepezil administration (4h DNPZ) to predict cognitive responses after 6months of medication. CERAD neuropsychological assessment battery was used to define cognitive response at 6months. We compared 4h DNPZ to baseline single photon emission tomography (SPECT) by statistical parametric mapping to identify perfusion changes in responders (N = 16) and non-responders (N = 7). In responders, there were significant relatively increase in perfusion in left parietal lobe (BA39, 7, 1), right superior frontal gyrus (BA6) and right middle occipital gyrus (BA39). In the non-responders, perfusion was relatively increase in the left parietal lobe (BA39) only. In an explorative analysis, we found a significant correlation between perfusion changes in right BA6 and CERAD score changes at 6months. Different SPECT perfusion changes at 4h after donepezil administration were demonstrated in the group of responders and non-responders with potential correlation with CERAD score change. Thus, 4h DNPZ brain perfusion SPECT can be used to predict donepezil response at 6months.
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