Abstract
The failure of small-caliber vascular grafts still means a serious problem. Concerning the early postoperative complications we aimed to investigate the hemostaseological and hemorheological aspects of this issue in a canine model. In the Control group only anesthesia was induced. In the Grafted group under general anesthesia a 3.5-cm segment was resected unilaterally from the femoral artery and replaced with a PTFE graft (diameter: 3 mm). On the 1st-3rd-5th-7th and 14th postoperative days the skin temperature of both hind limbs was measured, and blood sampling occurred for hematological, hemostaseological and hemorheological tests. The skin temperature of the operated versus intact limbs did not differ. In the Grafted group leukocyte count was elevated by the 1st postoperative day, while platelet count increased over the entire follow-up period. Fibrinogen concentration rose on the 1st-5th days, activated partial thromboplastin time increased on the 3rd-7th days. Erythrocyte aggregation was enhanced significantly on the 1st-5th days. In specimens taken on the 14th day, histologically we found matured thrombus narrowing the graft lumen. Small-caliber PTFE graft implantation into the femoral artery caused significant changes in several hemostaseological and hemorheological parameters. However, better clarifying the factors leading to early thrombosis of these grafts needs further studies.
Highlights
Open surgical procedures, such as bypass operations still have an important role in today’s vascular surgery[1,2,3,4,5]
All experimental animals survived the operations and there was no death during the 2-week postoperative follow-up period
The motion of the animals were normal during the 2-week follow-up period, there was no sign for hind limb circulatory problem
Summary
Open surgical procedures, such as bypass operations still have an important role in today’s vascular surgery[1,2,3,4,5]. The patient’s superficial vein or artificial vascular graft is used, what can be made of polyethylene terephthalate (PTE, Dacron®) or polytetrafluoroethylene (PTFE). Bypass surgeries made with the patients’ own veins are statistically proved to have twice as more patency rates than the artificial grafts[6,7,8]. In case of the surgeries above the knee the implantation of an artificial graft is chosen since with progression of the underlying disease it might be the necessary to do surgery below the knee, where veins are preferred for the bypass[4,5,6]
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