Early postoperative calculation of the tacrolimus concentration-to-dose ratio does not predict outcomes after kidney transplantation.

Abstract

There is emerging interest in the tacrolimus metabolism rate as it is linked to outcomes after transplantation (1-7). We and others propose the concentration-to-dose (C/D) ratio as a simple surrogate for the individual tacrolimus (Tac) metabolism rate (5;8;9). Recently, Jouve et al. showed in a large retrospective single-center study that the C/D ratio was in contrast to the CYP3A5 genotype strongly associated with outcomes after renal transplantation (RTx)(3).