Abstract
Introduction A number of genes have been associated to the development of schizophrenia, several of which are involved in central nervous system development. It has also been suggested that exposure to viral infections during early life increases the risk for later developing schizophrenia. In this study we investigate if an early postnatal infection by influenza A/WSN/33 virus in mice can cause changes in the expression of genes, including genes associated with schizophrenia, in the brain during development and if the early life infection affect the behavior in adult mice. In addition to wild type mice, an immunodeficient strain (Tap1-/-) was included in the study to model the potential influence of a genetic immune dysfunction.
Highlights
A number of genes have been associated to the development of schizophrenia, several of which are involved in central nervous system development
In this study we investigate if an early postnatal infection by influenza A/WSN/33 virus in mice can cause changes in the expression of genes, including genes associated with schizophrenia, in the brain during development and if the early life infection affect the behavior in adult mice
Postnatal infection by influenza A virus can affect the expression of schizophrenia-associated genes during development and affect cognitive and emotional functions in adult animals
Summary
Infectious diseases of the nervous system: pathogenesis and worldwide impact Roberto Bruzzone, Monique Dubois-Dalcq, Georges E Grau, Diane E Griffin and Krister Kristensson Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here.
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