Abstract
BackgroundPatients who are slated for bariatric surgery vary in terms of their age at onset of obesity, duration of obesity, and their health complications. Therefore, we aimed to explore a relationship between the age at onset of obesity, metabolic parameters, and health problems in bariatric surgery candidates.MethodsA total of 469 unrelated adults with obesity prior to bariatric surgery were included in this study. The study group consisted of 246 individuals who became obese < 20 years of age, and 223 individuals who became obese ≥ 20 years. Clinical, biochemical, anthropometric assessments, and DXA-derived measures were taken.ResultsPatients with early onset of obesity had a higher total body fat mass, and higher body fat percentage, and a 1.84 times higher risk of BMI above 40 kg/m2 than patients with adult onset of obesity (≥ 20 years). Multivariable logistic regression demonstrated that, among bariatric surgery candidates with early onset of obesity, the frequency of hypertension and type 2 diabetes was significantly lower than that in cases with an adult onset of obesity, despite a longer duration of obesity and higher BMI.ConclusionsThe age at which an individual reaches obesity has a significant impact on patient characteristics on the day he or she is evaluated for bariatric surgery. A younger age at obesity onset is a predicting factor for a higher BMI in patients, but they are less likely to clinically manifest well-established consequences of obesity, such as diabetes or hypertension, compared to patients with adult onset of obesity.
Highlights
Obesity is a complex chronic disease, characterized by an increase in body mass due to the growth of the boy’s fat tissues, leading to the development of numerous health complications
Participating in this study were 246 individuals who had been obese since before the age of 20 years, whose median age at onset of obesity was 7.0 (IQR 6.0–10.0) years, and 223 individuals who had become obese at age 20 or older, whose median age at onset of obesity was 29.0 (IQR 24.0–40.0) years
We found significant differences in terms of obesity duration, weight, body mass index (BMI), body fat percentage, body fat mass, fasting glucose, HbA1C, and Apnea– Hypopnea Index (AHI) between the two groups (Table 1)
Summary
Obesity is a complex chronic disease, characterized by an increase in body mass due to the growth of the boy’s fat tissues, leading to the development of numerous health complications. Patients applying for bariatric surgery vary with respect to age at onset of obesity and duration of obesity, and with respect to the severity of any obesity-related complications Evaluating these differences is crucial in the approach to the candidate for bariatric surgery. This issue is the subject of our further research, and the aim of this study was to assess differences in patient characteristics prior to bariatric surgery in relation to age at onset of obesity and the risk of obesity-related diseases, such as type 2 diabetes, hypertension, dyslipidemia, obstructive sleep apnea (OSA), and non-alcoholic fatty liver disease (NAFLD). Biochemical, anthropometric assessments, and DXA-derived measures were taken
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