Abstract
In their valuable study, Snoek and co-workers1 reported 88 infants (≤ 3 days old, gestational age ≥34 weeks) with early-onset sepsis (EOS) and/or meningitis (EOM) due to group B streptococcus (GBS, n = 81) or E.coli (n = 7). Cases came from the Dutch prospective nationwide cohort study (2018–2021). Actual treatment performed under Dutch guidelines was compared with hypothetical indications from NICE guidelines and the US early-onset sepsis calculator (EOSC). EOSC would have led to delayed antibiotic treatment in significantly more cases than Dutch and NICE guidelines.
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