Abstract
BackgroundThere are still controversies about the integration of breast cancer as a part of the disease spectrum in Lynch syndrome.MethodsA regular follow-up of a Lebanese pedigree with Lynch syndrome due to a point mutation of MSH2 gene at the splice donor site of intron 3 started in 1996.ResultsA 26-year-old pregnant woman, mutation carrier, developed an aggressive breast cancer, refractory to standard chemotherapy regimens. The microsatellite analysis of the tumor showed an unstable pattern for markers BAT25 and BAT26. The immunohistochemical staining was negative for MSH2 and MSH6 and normal for MLH1 and PMS6 enzymes.ConclusionThe segregation of the mutation with the disease phenotype and these results suggest that MSH2 inactivation may be involved in the accelerated breast carcinogenesis and might be considered in the cancer screening program.
Highlights
There are still controversies about the integration of breast cancer as a part of the disease spectrum in Lynch syndrome
The identification of the germline mutation in a Lynch syndrome family allows mutation carriers to be included in lifesaving cancer surveillance programs [1]
Most genetic and immunohistochemical studies on familial and sporadic breast cancers did not evoke any strong relationship with the mismatch repair (MMR) gene defect
Summary
A 26-year-old pregnant woman, mutation carrier, developed an aggressive breast cancer, refractory to standard chemotherapy regimens. The microsatellite analysis of the tumor showed an unstable pattern for markers BAT25 and BAT26. The immunohistochemical staining was negative for MSH2 and MSH6 and normal for MLH1 and PMS6 enzymes
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