Abstract

Infant rats treated with 6-hydroxydopamine (6-OHDA) showed normal experience-dependent odor preferences. Adult rats that had been neonatally drug treated retained infantile odor preferences while controls did not. Exposing juveniles to a new odor for 10 days changed the preferences of controls but not of neonatally drug-injected animals. Juveniles in the two treatment groups habituated similarly to a novel object, indicating that drug treatment did not produce a general inability to ignore irrelevant stimuli. Neonatal 6-OHDA treatment reduced concentrations of norepinephrine but not dopamine in the adult olfactory cortex. Norepinephrine may be a substrate for infantile amnesia.

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