Abstract
Background Lymph node metastasis (LNM) is a relatively rare event in soft tissue sarcoma. An association between the timing of LNM detection and patient prognosis is presently unknown. Patients and Methods We retrospectively analyzed the clinicopathological features of 33 patients with LNM between 2001 and 2015. Analysis of the timing of LNM diagnosis was grouped according to patients presenting LNM in either <8 months (the median time from primary tumor diagnosis to LNM) or ≥8 months after primary tumor diagnosis. Results A relationship between the primary tumor size and the timing of the LNM was not significantly found (Rs = 0.0088, p=0.96). Sixteen patients had an LNM detection duration of <8 months, and 17 patients had a duration of ≥8 months. The 5-year survival for patients with an LNM detection duration of <8 months and ≥8 months was 19% and 71%, respectively (p=0.0016). There were 19 patients with pulmonary metastases. Among them, there were 13 patients with a duration of primary tumor diagnosis to LNM of <8 months and 6 with a duration of ≥8 months (p=0.01). Conclusion Early LNM (<8 months) may predict poor prognosis in soft tissue sarcoma.
Highlights
Distant metastasis is common in patients with soft tissue sarcoma (STS) of the extremities, occurring in about 25% of patients [1, 2]
The precise role of lymphadenectomy remains to be defined because Lymph node metastasis (LNM) in patients with STS is rare, thereby
International Journal of Surgical Oncology limiting the feasibility of well-designed prospective studies to establish the role of lymphadenectomy. ere are some reports describing an association between the time from the primary STS diagnosis to LNM and patient prognosis [10, 11]
Summary
An association between the timing of LNM detection and patient prognosis is presently unknown. We retrospectively analyzed the clinicopathological features of 33 patients with LNM between 2001 and 2015. A relationship between the primary tumor size and the timing of the LNM was not significantly found (Rs 0.0088, p 0.96). Sixteen patients had an LNM detection duration of
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