Abstract
BackgroundTriclosan is an antimicrobial agent that may affect the gut microbiome and endocrine system to influence adiposity. However, little data from prospective studies examining prenatal and childhood exposures exist. We investigated the relationship between multiple, prospective early life measure of triclosan exposure and child adiposity. MethodsIn a prospective cohort of 220 mother-child pairs from Cincinnati, OH (enrolled 2003–2006), we quantified triclosan in urine samples collected twice during pregnancy, annually from 1 to 5 years of age, and once at 8 years. We assessed child adiposity at age 8 years using body mass index (BMI), waist circumference, and bioelectric impedance. We estimated covariate-adjusted associations of child adiposity with a 10-fold increase in average prenatal, average early childhood (average of 1–5 years), and 8-year triclosan concentrations.ResultsAmong all children, there was no association between triclosan and child adiposity. While urinary triclosan concentrations at all three time periods were weakly, imprecisely, and inversely associated with all three measures of adiposity among girls, these associations did not differ significantly from those in boys (sex x triclosan p-values> 0.35). Among girls, the strongest associations were generally observed for prenatal triclosan when we adjusted for all three triclosan concentrations and covariates in the same model; BMI z-score (β: -0.13; 95% CI: -0.42, 0.15), waist circumference (β: − 1.7 cm; 95% CI: -4.2, 0.7), and percent body fat (β :-0.6; 95% CI: -2.7, 1.3). In contrast, the associations between triclosan concentrations and adiposity measures were inconsistent among boys.ConclusionWe did not observe evidence of an association of repeated urinary triclosan concentrations during pregnancy and childhood with measures of child adiposity at age 8 years in this cohort.
Highlights
Triclosan is an antimicrobial agent that may affect the gut microbiome and endocrine system to influence adiposity
We examined the relationship between prenatal, early childhood, and concurrent urinary triclosan concentrations with measures of adiposity at age 8 years
We examined whether prenatal, early childhood, or concurrent urinary triclosan concentrations were associated with differences in body mass index (BMI) z-score, waist circumference, and percent body fat at age 8 years using multivariable linear regression
Summary
Triclosan is an antimicrobial agent that may affect the gut microbiome and endocrine system to influence adiposity. We investigated the relationship between multiple, prospective early life measure of triclosan exposure and child adiposity. Over the last 30 years the prevalence of childhood obesity has doubled in the United States; in 2012, over one-third of children and adolescents were either overweight or obese [1]. Increased adiposity can elevate the risk of cardiovascular disease, type 2 diabetes, Triclosan is a widely used antimicrobial chemical found in some household and personal care products, including toothpaste, mouthwash, soaps, deodorants, textiles, toys, medical devices, and kitchenware [6, 7]. Triclosan may impact obesity risk either by changing the composition of the gut microflora or endocrine disruption
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