Abstract
Asthma is the most common inflammatory disease affecting the lungs, which can be caused by intrauterine or postnatal insults depending on the exposure to environmental factors. During early life, the exposure to different risk factors can influence the microbiome leading to undesired changes to the immune system. The modulations of the immunity, caused by dysbiosis during development, can increase the susceptibility to allergic diseases. On the other hand, immune training approaches during pregnancy can prevent allergic inflammatory diseases of the airways. In this review, we focus on evidence of risk factors in early life that can alter the development of lung immunity associated with dysbiosis, that leads to asthma and affect childhood and adult life. Furthermore, we discuss new ideas for potential prevention strategies that can be applied during pregnancy and postnatal period.
Highlights
Frontiers in MedicineCitation: Cereta AD, Oliveira VR, Costa IP, Guimarães LL, Afonso JPR, Fonseca AL, Sousa ARTd, Silva GAM, Mello DACPG, Oliveira LVF and da Palma RK (2021) Early Life Microbial Exposure and Immunity Training Effects on Asthma Development and Progression. Front. Med. 8:662262
Asthma is the most common heterogeneous inflammatory lung disease appearing generally in childhood
We focus on evidence of risk factors in early life that can alter the development of lung immunity associated with dysbiosis, that leads to asthma and affect childhood and adult life
Summary
Citation: Cereta AD, Oliveira VR, Costa IP, Guimarães LL, Afonso JPR, Fonseca AL, Sousa ARTd, Silva GAM, Mello DACPG, Oliveira LVF and da Palma RK (2021) Early Life Microbial Exposure and Immunity Training Effects on Asthma Development and Progression. Front. Med. 8:662262.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
