Early life exposure to noise alters the representation of auditory localization cues in the auditory space map of the barn owl

Abstract

The auditory space map in the optic tectum (OT) (also known as superior colliculus in mammals) relies on the tuning of neurons to auditory localization cues that correspond to specific sound source locations. This study investigates the effects of early auditory experiences on the neural representation of binaural auditory localization cues. Young barn owls were raised in continuous omnidirectional broadband noise from before hearing onset to the age of ∼ 65 days. Data from these birds were compared with data from age-matched control owls and from normal adult owls (>200 days). In noise-reared owls, the tuning of tectal neurons for interaural level differences and interaural time differences was broader than in control owls. Moreover, in neurons from noise-reared owls, the interaural level differences tuning was biased towards sounds louder in the contralateral ear. A similar bias appeared, but to a much lesser extent, in age-matched control owls and was absent in adult owls. To follow the recovery process from noise exposure, we continued to survey the neural representations in the OT for an extended period of up to several months after removal of the noise. We report that all the noise-rearing effects tended to recover gradually following exposure to a normal acoustic environment. The results suggest that deprivation from experiencing normal acoustic localization cues disrupts the maturation of the auditory space map in the OT.