Early life adversity is associated with attenuated testosterone reactivity to acute stress among adolescents

Abstract

Understanding how testosterone responds to stress or challenge may be integral to uncovering biological pathways to potentially harmful behaviors like aggression. Yet, studies investigating patterns of testosterone reactivity under stress within adolescent populations are limited. Among those conducted, even fewer have investigated environmental factors which may shape such patterns. Exposure to early life adversity (ELA) has been shown to influence other biological markers of stress reactivity, though how it may be associated with alterations in testosterone reactivity remains underexplored. The current study addresses these gaps by examining salivary testosterone concentrations across the administration of a Trier Social Stress Test for Children in a sample of 87 adolescents (46.4% female, Mage = 13.91 years, SDage = 1.57). The current study tested two central hypotheses: (1) that testosterone would rise in response to a standardized laboratory stressor, and (2) that greater ELA would be associated with higher baseline (or, pre-stress) testosterone scores and a dampened testosterone response to stress. Adolescents in the current sample showed a robust increase in testosterone following administration of the TSST-C, supporting the limited previous findings which indicate testosterone does mount an acute stress response in adolescents. Contrary to hypotheses, ELA was not associated with significant elevations in baseline testosterone scores. However, ELA was associated with dampened testosterone reactivity, even after controlling for important demographic and biological factors. Methodological implications, including considerations for researchers aiming to capture an acute testosterone response, as well as how our understanding of ELA’s role in adolescent biological functioning is extended by our findings regarding testosterone, are discussed.