Abstract
In uraemia patients aluminium (Al) accumulation in bone leads to low turn-over bone disease [4]. Al-related bone disease causes bone pain, non-traumatic fractures and hypercalcaemia, and does not respond to treatment with vitamin D compounds [9]. Al-contaminated dialysate and ingestion of Al-containing phosphate binding agents are the main risk factors for bone Al accumulation [6, 12]. Studies of selected patients have indicated that Al-related bone disease ameliorates after successful kidney transplantation [5, 10], but systematic studies of bone Al have not been reported. In a prospective study we investigated the effect of successful kidney transplantation on bone Al and clinical bone disease. Kidney transplantation; Aluminium; Related bone disease
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