Abstract
INTRODUCTION: P-glycoprotein (Pgp) is a transmembrane protein expressed in many cell types. We identified a protein in human breast milk that cross-reacts with Pgp antibody. This Pgp-like factor (Pgp-F) binds to intestinal epithelial cells. p38 MAP Kinase has multiple roles in inflammation and may have a role in binding of protective factors. We hypothesize that Pgp-F binding protects against bacteria-induced inflammation via a p38 MAP kinasedependent mechanism.
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