Abstract
Objectives:The objective of this study was to define the association between the burden of severe hypoxemia (SpO2≤70%) in the first week of life and development of severe ICH (grade III/IV) in preterm infants.Study Design:Infants born <32 weeks or weighing <1500g underwent prospective SpO2 recording from birth through 7d. Severe hypoxemia burden was calculated as the percentage of the error-corrected recording where SpO2≤70%. Binary logistic regression was used to model the relationship between hypoxemia burden and severe ICH.Results:A total of 163.3 million valid SpO2 data points were collected from 645 infants with mean EGA=27.7±2.6 weeks, BW=1005±291g; 38/645 (6%) developed severe ICH. There was a greater mean hypoxemia burden for infants with severe ICH (3%) compared to those without (0.1%) and remained significant when controlling for multiple confounding factors.Conclusion:The severe hypoxemia burden in the first week of life is strongly associated with severe ICH.
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