Abstract
Hearing threshold changes occurred relative to baseline at both one and two weeks after onset of aminoglycoside therapy. To assess changes in audiometric hearing thresholds between pre-treatment values and two weeks into therapy. To document observed changes, and occurrence of ototoxicity within the period. Prospective analytical cohort study on drug-resistant tuberculosis patients. Basic demographic parameters were taken. Three-point audiometric assessments within two weeks into therapy were done. Percentage of patients with ototoxicity were calculated. Pure tone threshold changes between the three audiometric values were compared. Audiograms of 53 patients comprising 56.6% males; age range was 13 to 91 years. Both air and bone conduction hearing thresholds significantly worsened between baseline and one week into therapy (p=0.011, and 0.015 respectively), and between baseline and two weeks into therapy (p=0.003 and 0.042 respectively). Minimal insignificant reduction occurred between both air and bone conduction hearing values of week 1 and week 2 of therapy (p= 1.000 and 0.856 respectively). By audiometric criteria, 4 patients (7.5%) developed ototoxicity within two weeks of treatment. Audiometric assessments within two weeks into therapy with anti-tuberculous therapy may not represent baseline audiometry. 7.5% of the patients developed ototoxicity within two weeks of therapy.
Highlights
Pure tone audiometry is the simplest subjective audiological assessment of hearing levels in adults
Audiometric assessments are employed in serial monitoring of hearing levels in patients that are predisposed to worsening of hearing by virtue of occupation or administration of potentially ototoxic medications
Data of seventeen patients were excluded comprising 7 patients that had commenced intensive phase of therapy from the community, 8 patients who became acutely sick and weak within the two weeks on medications, could not complete the three audiometry assessments and 2 patients who died within two weeks on therapy
Summary
Pure tone audiometry is the simplest subjective audiological assessment of hearing levels in adults. Audiometric assessments are employed in serial monitoring of hearing levels in patients that are predisposed to worsening of hearing by virtue of occupation or administration of potentially ototoxic medications. Objectives: To assess changes in audiometric hearing thresholds between pre-treatment values and two weeks into therapy. Results: Audiograms of 53 patients comprising 56.6% males; age range was 13 to 91 years Both air and bone conduction hearing thresholds significantly worsened between baseline and one week into therapy (p=0.011, and 0.015 respectively), and between baseline and two weeks into therapy (p=0.003 and 0.042 respectively). Hearing threshold changes and peculiarities of audiometric assessments among patients in a drug-resistant tuberculosis treatment center.
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