Abstract

Pediatric severe sepsis and septic shock is one of leading causes of death in PICU. Although antibiotics and comprehensive treatments have continuous improvements, its mortality rate is still high. Present study confirms early goal-directed therapy can significantly reduce the mortality of severe sepsis and septic shock. The purpose is to introduce the early goal-directed therapy protocol and to guide Chinese pediatrician to improve outcome of pediatric severe sepsis and septic shock and increase the survival rate in clinical practice. Key words: Sepsis; Severe sepsis; Treatment; Early goal-directed therapy

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