Abstract
Background: It is well known that pancreatobiliary reflux is considered an important factor for the carcinogenesis of the biliary system in patients with pancreaticobiliary maljunction. Recently, our studies have indicated that pancreatobiliary reflux can occur not only in patients with pancreaticobiliary maljunction but also in those with a normal pancreaticobiliary junction, and could be associated with the occurrence of gallbladder carcinoma. The aim of the present study was to examine the incidence of gallbladder carcinoma associated with pancreatobiliary reflux.
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