Early enteral nutrition support of spontaneous intraventricular hemorrhage-induced coma patients

Abstract

Objective To investigate the strategy and efficacy of enteral nutrition support of patients with spontaneous intraventricular hemorrhage-induced coma. Methods 139 patients were randomly divided into study group (treated with enteral nutrition mixed suspension, n=67) and control group (treated with normal full nutritional homogenized product, n=72) with a random number generating software. Enteral nutrition support was administered in 6-48 hours after admission. The total daily intake of enteral nutrition preparation was 1 000 ml(4 186.8 kJ), supplemented by liquid food. Body weight, serum albumin, serum total protein, hemoglobin, lymphocyte count, incidence of infection, level of consciousness and incidence of complications were compared between the two groups. Results In the third week after onset, the serum albumin [(32.1±3.3)g/L vs. (30.5±2.3)g/L, P=0.041], total protein [(62.2±3.2)g/L vs. (56.9±2.7)g/L, P=0.039], and hemoglobin [(125.5±5.7)g/L vs. (120.7±6.4)g/L, P=0.027] were significantly higher in the study group than in the control group. The Glasgow score in the second week in the study group was 13.1±1.9, significantly higher than that in the control group (11.0±2.3)( P=0.037); the incidence of nosocomial infection was significantly lower in the study group than in the control group [17.9%(12/67)vs. 29.2%(21/72), P=0.021]; the proportion of patients with abnormal blood test results and that of patients having fever for more than 7 consecutive days were both significantly lower in the study group than in the control group [31.3%(21/67)vs. 38.8%(28/72), P=0.042; 37.3%(25/67)vs. 41.7%(30/72), P=0.047]. The two groups showed no significant difference in the incidence of intracranial infection after external ventricular drainage(P=0.235). Conclusion For patients with spontaneous intraventricular hemorrhage-induced brain dysfunction, enteral nutrition support with enteral nutrition suspension could effectively improve nutritional status, reduce complications, therefore conducive to recovery. Key words: Spontaneous intraventricular hemorrhage; Enteral nutrition; Early stage