Abstract
We have demonstrated that removal of the parathyroid glands in the hamster results in an increased urinary excretion of calcium which accompanies a fall in serum calcium (Biddulph & Gallimore, 1972). In the present study we investigated the early effects of parathyroidectomy (PTX) in this species to determine how rapidly inhibition of parathyroid hormone (PTH) secretion can alter urinary excretion and serum concentration of calcium. Male golden hamsters, Mesocricetus auratus (Engle Laboratories, Farmersburg, Indiana) weighing 85–90 g, were fasted 40 h before treatment. Animals were PTX by surgical excision or sham-operated and immediately injected i.v. with 5 or 65 U.S.P. units parathyroid extract (PTE, donated by Eli Lilly and Co., Indianapolis, Indiana) or vehicle (acidified isotonic saline, pH 3·2). Urine samples were collected as previously described (Biddulph, 1972) for various periods, and blood samples obtained at the end of each collection interval. Protein-bound and ultrafiltrable fractions of serum calcium were
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