Abstract
Introduction: Early donor specific HLA-antibodies (DSA) developing after lung transplantation are associated with increased chronic rejection and mortality. Regulatory T cells (Treg) have the potential to regulate alloantigens and thus may counteract the development of chronic rejection in lung transplantation. Natural killer (NK) cells play a key role in host defense due to their ability to release cytokines and to mediate cytolytic activity. B cells are important players in the immune system as antigen presenters. In this study, we investigate the interdependency of the cellular immune phenotype and the development of early donor specific antibodies (DSA) in peripheral blood after clinical lung transplantation.
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