Abstract
The steady increase in the number of autoimmune diseases and immune-mediated autoinflammatory processes causes an increased interest of doctors of all specialties in this topic and makes the issue of early detection of autoimmune disorders / autoimmune syndrome (AS) extremely urgent. These disorders often develop against the backdrop of an atypical stream of chronic active viral infections caused by persistent viruses, in particular those of the Herpesviridae family, and remain undiagnosed due to polysymptomatic disease, and various “clinical masks” of the disorders caused by them. The semi-quantitative method developed by us for screening assessment of the content of autoantibodies in the blood serum of patients suffering from ACAI caused by herpes viruses using the ELISA method (Immunodot) is a highly specific screening method that can allow for an objective assessment of the dynamics of the autoimmune process, as well as control the effectiveness of the ongoing complex antiviral and immunomodulatory therapy. The detection of autoantibodies of various specificity in the blood serum of patients suffering from an atypical chronic active infection caused by herpes viruses (ACAI) is an early diagnostic marker, necessary, first of all, to identify autoimmune pathology of the nervous system, which is associated with a long course of the active mixed herpes-viral process.
Highlights
IntroductionThe steady increase in the number of autoimmune diseases and immune-mediated auto-inflammatory processes provokes growing interest of doctors of all specialties in this topic and makes the issue of early detected autoimmune disorders/autoimmune syndrome (AS) extremely urgent [2, 9]
The steady increase in the number of autoimmune diseases and immune-mediated auto-inflammatory processes provokes growing interest of doctors of all specialties in this topic and makes the issue of early detected autoimmune disorders/autoimmune syndrome (AS) extremely urgent [2, 9]. These disor ders often develop in parallel with aberrant input of chronic active viral infections caused by persistent viruses, those of the Herpesviridae family, and remain undiagnosed due to polysymptomatic picture, as well as diverse related “clinical masks” [3, 4, 7]
The prevailing spectrum and a certain level of anti-ganglioside autoantibodies identified by us in patients suffering from active infection caused by herpes viruses (ACAI) caused by herpes viruses allow us to assess the activity of virus-induced autoaggression and to dynamically monitor effectiveness of the ongoing complex antiviral and immunomodulatory therapy
Summary
The steady increase in the number of autoimmune diseases and immune-mediated auto-inflammatory processes provokes growing interest of doctors of all specialties in this topic and makes the issue of early detected autoimmune disorders/autoimmune syndrome (AS) extremely urgent [2, 9]. These disor ders often develop in parallel with aberrant input of chronic active viral infections caused by persistent viruses, those of the Herpesviridae family, and remain undiagnosed due to polysymptomatic picture, as well as diverse related “clinical masks” [3, 4, 7]. Cases of co- and mixed infections caused by viruses of this family have been described at increasingly higher rate
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