Abstract

 
 
 The high incidence of concomitant pathology on the part of the renal system can lead to a mutual burden of various diseases, which in turn requires additional methods of examination, prevention, and further mandatory medical correction in patients with chronic obstructive pulmonary disease.Objective: to identify a moderately increased albuminuria and analysis of the functional state of the kidneys in chronic obstructive pulmonary disease in low altitude at an earlier stage of its manifestation.Material and methods: 82 low-altitude patients (Tokmok) were examined with COPD of varying severity, as well as 10 healthy individuals. The average age was 60.53 + 15.48 years. In addition to general clinical examination, patients underwent an early marker of damage to the MIA, assessment of the function of external respiration and indicators of renal function, which included the calculation of glomerular filtration rate (GFR), analyzes of proteinuria, leukocyturia, hematuria, total protein and serum creatinine.Results: In patients with COPD, an early and significant change in renal function indices is noticeably observed, which in turn tends to correlate with the degree of bronchial obstruction.
 
 
Highlights
Chronic obstructive pulmonary disease (COPD) and diseases of the genitourinary system in combination, according to various studies, ranges from 32% [1] to 47.3% [2]
Compared with the control group, COPD patients had significantly low rates of filtration function and this was expressed in an increase in serum creatinine concentration, as well as in a decrease in eGFR
Our study revealed a progressive increase in moderately increased albuminuria (MIA) in low altitude (Tokmok) as the course of COPD worsens, which coincides with data from several scientific publications [32,33,34] on the relationship of the degree of hypoxemia in this disease with a violation of the glomerular filtration barrier
Summary
Chronic obstructive pulmonary disease (COPD) and diseases of the genitourinary system in combination, according to various studies, ranges from 32% [1] to 47.3% [2]. Many studies indicate a high frequency of changes in the kidneys in patients with COPD, which is 60.5% by sectional data [3].
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