Early diagnosis of Chikungunya virus utilizing square core photonic crystal fiber (SC-PCF) with extremely high relative sensitivity

Abstract

Chikungunya virus (CHIKV) poses a significant public health threat due to its capacity to cause widespread and debilitating outbreaks. The virus is responsible for CHIKV fever, a disease characterized by severe joint pain, sudden onset of fever, headache, muscle pain, and rash. The virus has been reported in various regions globally, with outbreaks occurring in parts of Africa, Asia, the Americas, and the Indian subcontinent. Consequently, the scientific community expends substantial efforts in developing dependable, rapid, highly sensitive, and cost-effective techniques in order to identify the CHIKV virus. In this study, an innovative biomedical sensor using photonic crystal fiber technology enables precise detection of the CHIKV virus through uric acid, normal and infected plasma, red blood cells, and platelets in the blood. The introduced sensor identifies those kinds with extremely increased relative sensitivity and minimal losses in contrast to alternative photonic crystal fiber-based biosensors. The introduced sensor showcases a minimal confinement loss of 2.25 × 10− 13 cm− 1, a relative sensitivity of 99.37%, an effective area of 1.36 × 105 µm2, with a minimal effective material loss of 0.001966 cm–1, a numerical aperture of 0.1874, and low dispersion of 0.06. Also, the demonstrated sensor is able to function within the terahertz spectrum, covering a substantial span from 0.8 to 2.6 THz. Furthermore, an extensive comparison analysis is performed between the showcased sensor and related literature on photonic crystal fibers to verify the reliability and effectiveness of the introduced structure.