Abstract
In this study, we evaluated the diagnostic and prognostic value of the neutrophil gelatinase-associated lipocalin-2 (NGAL) level in urine as an early marker of renal dysfunction in preterm infants with very low and extremely low body weight. Aim - evaluation of diagnostic and prognostic significance of the urinary NGAL level as an early biomarker of acute kidney injury (AKI) in preterm infants. Materials and methods. The study included 104 premature babies, 78 of which formed the main group (AKI), and 26 babies - the comparison group (non-AKI). The main criterion for acute kidney injury in neonates according to neonatal classification AKIN (2011) is creatinine level > 1.5 mg/dL at the age of not earlier than 48 hours after birth. Results. The study identified a statistically significant correlation in the level of NGAL in the urine of children from the main and comparison groups. Conclusion. Biomarkers of kidney damage can give more accurate information than creatinine for the early diagnosis of AKI in children. In a comprehensive assessment of a child, it is necessary to take note of the indicators of renal function (creatinine, GFR) and biomarkers of injury (NGAL). This approach will allow performing the diagnostics and therapy of early AKI in children based on structural and functional criteria.
Highlights
В данном исследовании проведена оценка диагностической и прогностической значимости уровня липокалина-2, ассоциированного с нейтрофильной желатиназой (NGAL), в моче как раннего маркера нарушения функции почек у недоношенных новорожденных с очень низкой и экстремально низкой массой тела
We evaluated the diagnostic and prognostic value of the neutrophil gelatinaseassociated lipocalin-2 (NGAL) level in urine as an early marker of renal dysfunction in preterm infants with very low and extremely low body weight
The main criterion for acute kidney injury in neonates according to neonatal classification AKIN (2011) is creatinine level ≥ 1.5 mg/dL at the age of not earlier than 48 hours after birth
Summary
EARLY DIAGNOSIS OF ACUTE KIDNEY INJURY IN PRETERM INFANTS USING URINARY NGAL BIOMARKER. В данном исследовании проведена оценка диагностической и прогностической значимости уровня липокалина-2, ассоциированного с нейтрофильной желатиназой (NGAL), в моче как раннего маркера нарушения функции почек у недоношенных новорожденных с очень низкой и экстремально низкой массой тела. Цель — оценка диагностической и прогностической значимости уровня NGAL в моче как раннего маркера ОПП у недоношенных новорожденных с очень низкой и экстремально низкой массой тела. В ходе исследования определена статистически достоверная корреляция по уровню NGAL в моче у детей из сравниваемых групп. Биомаркеры почечного повреждения могут дать более точные данные, чем креатинин, для раннего диагноза ОПП у детей. Aim — evaluation of diagnostic and prognostic significance of the urinary NGAL level as an early biomarker of acute kidney injury (AKI) in preterm infants
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