Abstract
The relationship between gastroesophageal reflux disease (GERD) and Helicobacter pylori (H. pylori) eradication is still debated. Recently, we had a patient of GERD who had developed it shortly after H. pylori eradication therapy. A 72-year-old man was diagnosed by endoscopy as suffering from severe superficial gastritis in the stomach body. A rapid urease test showed H. pylori infection. He was then started on proton pump inhibitor (PPI) based therapy for two weeks eradicating H.pylori. After completion of H. pylori eradication, he complained of a heart-burn sensation. Follow-up endoscopy showed reflux esophagitis, of grade B according to the Los Angeles classification. Since the patient had developed GERD after completion of the triple therapy, their suggests that H. pylori eradication must have triggered the development of de novo GERD after a short period of time.
Highlights
Gastroesophageal reƀux disease (GERD) is a complex disorder, involving gastric acid coming up from the stomach into the esophagus
GERD symptoms occur in 25 % - 40 % of the general population
The relationship between GERD and H. pylori infection varies by geographic location.[1]
Summary
Gastroesophageal reƀux disease (GERD) is a complex disorder, involving gastric acid coming up from the stomach into the esophagus. Helicobacter pylori (H. pylori) is the key pathogenetic factor in gastritis, peptic ulcers, stomach cancer and mucosa-associated lymphoid tissue (MALT) lymphoma.[1] The pathogenesis of reƀux esophagitis is not fully understood.[2,3] In addition, the relationship between GERD and H. pylori eradication is still debated. We present a patient with obvious GERD which developed 14 days after proton pump inhibitor (PPI) based H. pylori eradication.
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