EARLY DETECTION OF POLYNEUROPATHY IN PATIENTS WITH HEREDITARY TRANSTHYRETIN AMYLOIDOSIS CARDIOMYOPATHY

Abstract

Hereditary Transthyretin Amyloidosis (hATTR) is a disorder that can present with cardiac, neurological, or mixed signs and symptoms. Patients with hATTR cardiomyopathy (CM), can show early neurological signs which lead to the eventual onset of neurological symptoms. Early detection of polyneuropathy among patients with hATTR-CM can identify candidates for new disease modifying therapies that could significantly reduce mortality and morbidity in these complex patients. The purpose of this study is to examine the role of systematic neurological examinations in patients with hATTR-CM.