Early Detection of Peripheral Neuropathy in Type II Diabetes Mellitus by SUDOSCAN

Abstract

Backgrounds: Sudomotor dysfunction is one of the earliest neurophysiologic abnormalities to manifest in distal small fiber neuropathy. SUDOSCAN ® was developed to provide a non invasive, quick, simple and quantitative measurement of sweat function. The aim of this study is to evaluate the value of SUDOSCAN in the diagnosis of neuropathy and its early detection. Methods: This is a case control study was conducted from March 2014 to December2014 on type2 diabetic patient in the center of diabetes and endocrine disease in AL-Najaf . Sweat function was evaluated by measuring the electrochemical skin conductance (ESC) of the hands and feet. Results: 100 patients with type 2 diabetes mellitus including 55 patients with peripheral neuropathy and 45 patients without peripheral neuropathy were involved in this case control study. Hands and feet conductance were lower in patients with type 2 diabetes with peripheral neuropathy when compared to patients with type 2 diabetes without neuropathy (with p value less than 0.001 for hands mean electrochemical skin conductance and feet mean electrochemical skin conductance). Conclusions: SUDOSCAN is a promising, screening tool to detect neuropathy in patients with diabetes mellites. This is a very simple test, easy-to-perform that can be done in the clinical setting in 3–5 min.