Abstract
Multiple sclerosis (MS) is a progressive inflammatory disease (neurodegenerative), and its diagnosis is very important. MicroRNAs (miR) are small, non-coding RNAs that are abnormally expressed in many diseases and have been identified as predictive biomarkers for the early detection of diseases. One of the best diagnostic biomarkers of MS is miR-155. In this report, a sensitive, low-cost, non-label electrochemical nano biosensor was used for miR-155 detection. The biosensor comprises a nanocomposite of single-walled carbon nanotubes (SWCNT) and polypyrrole (PPY) on the graphite sheet (GS) substrate which was modified with an aptamer as miR-155 capture probe. All electrochemical measurements were performed in the presence of Fe(CN)63-/4- as a redox probe. The biosensor has a dynamic range of 10 aM to 1 µM with a detection limit of 10 aM. Also, the fabricated biosensor was successfully used in human serum. According to the ease of preparation, almost low cost, good selectivity, repeatability, and reproducibility the proposed biosensor can be a promising candidate for early detection of MS.
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