Early detection of infectious complications during induction therapy for acute leukemia with serial C-reactive protein biomarker assessment

Abstract

Febrile neutropenia (FN) and blood stream infections (BSI) are major complications of induction treatment for acute leukemia. We assessed the predictive utility of C-reactive protein (CRP), an acute phase reactant, for FN and BSI during induction. CRP levels and dynamics were analyzed in 138 consecutive patients. FN and BSI occurred in 110 (80.3%) and 10 (7.5%) patients, respectively. Median peak CRP level in the 24-hours preceding FN was 7.5 mg/dl (0.2–38.1) vs. median peak CRP level of 5.11 mg/dl (0.2–23.1, p = .009) in patients without FN. CRP levels preceding BSI were 13.1 mg/dl (6.9–27.9) vs. 6.3 mg/dl (0.16–38.14, p = .011). CRP increase prior to event (ΔCRP) was higher among patients with BSI vs. patients without BSI (p = .013). CRP was predictive for FN (p = .009) and BSI (p = .01) on ROC curve analysis and was also independently associated with FN on multivariate analysis. In conclusion, CRP is a sensitive biomarker that precedes FN and BSI.