Abstract
By April 2020 physicians in the UK/France and the US recognized a unique hyperinflammatory syndrome characterized by fever, cardiovascular shock, and suspected SARS-CoV-2 infection and public health authorities published advisories concerning this entity. In the US, this has been called multisystem inflammatory syndrome in children (MIS-C). Two publications in this volume of The Journal of Pediatrics report data collected between April and July and results published following peer review online in early October 2020 that reflect the beginning of what would be a rapid transition from clinical experience to clinical evidence.
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