Abstract
The observation of neurofibrillary tangles (NFTs) without associated amyloid-beta (Aβ) in the brains of cognitively normal and cognitively impaired elderly individuals has, for many years, been a source of discussion and controversy. The term "primary age-related tauopathy" (PART) was introduced in 2014 and consensus guidelines for the condition were published [1]. The clinical manifestations of PART have been described (see [2] for review). A recent molecular imaging study suggested that mesial temporal tau load is associated with a decline in cognitive performance in those with no Aβ pathology [3].
Highlights
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Seventy-eight eligible participants from The University of Manchester Longitudinal Study of Cognition in Normal Healthy Old Age have been investigated for this study. They were assigned to one of four groups based on pathology at death: normal for age (n = 10), Alzheimer's disease (AD) (n = 27), possible Primary age-related tauopathy (PART) (n = 20) and definite PART (n = 21)
Summary
Citing this paper Please note that where the full-text provided on Manchester Research Explorer is the Author Accepted Manuscript or Proof version this may differ from the final Published version. Changes in visuospatial episodic memory can help distinguish primary age-related tauopathy from Alzheimer’s disease Seventy-eight eligible participants from The University of Manchester Longitudinal Study of Cognition in Normal Healthy Old Age have been investigated for this study.
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