Abstract
AbstractMice (Taconic Swiss) were fed a high‐fat (28% lard), low‐protein (8% casein), lipotropic‐deficient diet for 1–90 days. For 21 days parenchymal liposis was greatest in peripheral and outer middle zones of the lobule. During 21–90 days fat increased in central and middle zones and decreased in peripheral zones.Ceroid pigment developed in Kupffer cells within 12 days. During 31–45 days Kupffer cells coalesced and formed large ceroid globules which increased in size and number during the 46–90 day period. A reticular fibrosis surrounded the masses of ceroid.As early as seven days stromal distortion consisting chiefly of compression of reticulum by fat laden hepatocytes was prominent in peripheral lobular zones. Sinusoids were also obstructed and dilated by this process. Some became non‐functional and were transformed to fibrous cords. With progressive liposis (after 30 days) irregular stromal changes developed in all zones of lobules.
Published Version
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