Early case-fatality rates in elderly stroke patients do not increase when age increases

Abstract

We studied the association between age and survival after stroke. We particularly focused on deaths that could be attributed to the stroke lesion itself; that is, early death in severe stroke. A registry of all hospitalized stroke patients in Denmark included 93897 patients with information on stroke severity (Scandinavian Stroke Scale [SSS] 0-58), computed tomography, cardiovascular risk, age, sex and fatality within 1 month. Using regression models, we constructed age trajectories of 3-days, 1-week, and 1-month case-fatality rates unadjusted and adjusted for stroke severity, sex, and cardiovascular risk factors for patients with SSS <25 and SSS ≥ 25. The 3-days, 1-week, and 1-month case-fatality were 3.6%, 5.8% and 10.3%, respectively. Age-trajectories (SSS <25): 3-days case-fatality rates increased to the age of 75 years. Case-fatality rates then declined (unadjusted model) or leveled off (adjusted model) as age increased. One-week case-fatality increased to the age of 85 years. Case-fatality then leveled off (unadjusted model) or continued to rise (adjusted model) as age increased. One-month case-fatality rates increased throughout the entire lifespan. Age-trajectories (SSS ≥ 25): the leveling off phenomenon was still present for 3-days case-fatality; however, it was less pronounced. Very early stroke case-fatality rates increasing to the age of 75-85 years subsequently leveled off or even declined with increasing age. Advanced age per se should not be seen as a disadvantage in terms of surviving stroke in the very acute phase.