Abstract
Experiments in rabbits were conducted to study early neuropathological changes caused by the direct action of manganese on brain tissue. Manganese chloride (0.5 mg in 0.1 ml normal saline) was injected on alternate days into one of the lateral ventricles of the brain for 15 days. The injection of manganese chloride produced excitability in the form of convulsions. Electrocorticography at various intervals showed an arousal pattern at a frequency of 20–22 Hz, but after 9 days the amplitude was lessened in manganese-injected as compared to normal and saline-injected animals. Neuropathological changes of the early stages of manganese toxicity were in the form of scattered neuronal degeneration in cerebral and cerebellar cortex, small haemorrhagic areas in the pons and medulla oblongata. It has been possible to produce an experimental model in rabbits of early clinical manganese toxicity related to neuropathological changes, which shows alterations in electrocorticograms.
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