Abstract
After three days on a sugar and water diet, inbred Wistar rats received a single carcinogenic dose of dimethylnitrosamine (DMN). Kidney cells were grown in monolayer cultures in vitro from both treated and control animals at various intervals from 20 hr to seven days, following treatment. Cells isolated from treated rats as early as 20 hr following treatment had a prolonged life-span in vitro, exhibited morphological transformation and an increased mitotic index, produced colonies in methylcellulose gels, showed a high relative plating and growth efficiency and were agglutinated in the presence of Concanavalin A.
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