Abstract
Extremely low frequency electro-magnetic field (ELFF) exposure could induce hepatoma Bel-7402 and SMMC-7721 cells lines into early apoptosis without some significant effects to healthy hepatic cells HL-7702 cells in low exposure dose through affecting cellular membrane ion metabolism. Magnetic nanoFe3O4 particles (MNPs) presence with low effects to all hepatic cells lines strengthened ELFF bio-effects to tumor cells inducing more amount of tumor cells into early apoptosis with low effects to HL-7702 cells. Western-blot results indicated the early apoptosis signal channel Bcl protein family of tumor cells was activated significantly more effectively than HL-7702 cells due to higher MNPs uptake ratio of tumor cells and higher cellular membrane ion exchanging current than HL-7702 cells. Patch-clamp results showed MNPs combined with ELFF treatment inducing cells into early apoptosis should be partially based on ion metabolism disturbance of cells with similar to ELFF bio-effects to cells.
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