Early antiretroviral therapy reduced HIV-1 transmission in serodiscordant couples

Abstract

ACP Journal Club20 December 2011Early antiretroviral therapy reduced HIV-1 transmission in serodiscordant couplesMichael A. Polis, MD, MPHMichael A. Polis, MD, MPHNational Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA (M.A.P.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-155-12-201112200-02008 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationCohen MS, Chen YQ, McCauley M, et al; HPTN 052 Study Team. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011;365:493-505. https://pubmed.ncbi.nlm.nih.gov/21767103Clinical Impact RatingsGIM/FP/GP: Infectious Disease: References1 Dieffenbach CW, Fauci AS. Thirty years of HIV and AIDS: future challenges and opportunities. Ann Intern Med. 2011;154:766-71. [PMID: 21628350] Google Scholar2 Quinn TC, Wawer MJ, Sewankambo N, et al. Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group. N Engl J Med. 2000;342:921-9. [PMID: 10738050] Google Scholar3 Granich RM, Gilks CF, Dye C, De Cock KM, Williams BG. Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model. Lancet. 2009;373:48-57. [PMID: 19038438] Google Scholar4 Montaner JS, Lima VD, Barrios R, et al. Association of highly active antiretroviral therapy coverage, population viral load, and yearly new HIV diagnoses in British Columbia, Canada: a population-based study. Lancet. 2010;376:532-9. [PMID: 20638713] Google Scholar Author, Article, and Disclosure InformationAffiliations: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA (M.A.P.)This article was published at Annals.org on 6 December 2011. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 December 2011Volume 155, Issue 12Page: JC6-8KeywordsAdverse eventsAntiretroviral therapyGlobal healthHIVHIV-1Infectious diseasesPulmonary diseasesResearch laboratoriesTuberculosisViral load ePublished: 20 December 2011 Issue Published: 20 December 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...