Abstract

目的 研究门静脉高压症病人脾切除术后早期接受抗血栓治疗对预防门静脉血栓形成的效果及安全性.方法 将中山大学附属第三医院2003-2005年肝硬化门静脉高压症欲接受脾切除术的病人59例随机分为2组:早期使用抗凝、祛聚药物预防组与同期常规用药组为对照进行对比研究,利用彩色多普勒超声监测门静脉血栓形成情况.结果 52例完成随访6个月以上,随访率88.1%,其中预防组29例,对照组23例.术后对照组10 d内发生门静脉血栓1例,1个月内4例,1月后3例,合计8例(34.8%),1例为复发性血栓.预防组10 d内无一例发生门静脉血栓,1个月内2例,1个月后1例,合计3例(10.3%),两组病例门静脉血栓发病率差异有显著性(X2=4.59,P<0.05),3例并发上消化道出血.结论 门静脉高压症病人脾切除术后早期接受抗凝、祛聚治疗能降低术后门静脉血栓形成的发生率。

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