Abstract
ABSTRACT Certain aspects of peripheral thyroid hormone physiology were measured sequentially in subjects exposed to Pasteurella tularensis or vaccinated with a living attenuated strain of Venezuelan equine encephalomyelitis (VEE) virus. In both groups a significant rise in the per cent of unbound thyroxine (p <0.001) was observed within 24 hr following exposure to the infecting agent. In the tularemia group this elevation persisted for 3 days, then fell during the period of fever and clinical illness to reach a transient depression below normal. The per cent of free thyroxine then rose gradually to preinfection control levels. Following the initial rise in the vaccinated group, the per cent of unbound thyroxine continued to be elevated above preinfection control levels throughout the period of observation. The PBI in both groups fell initially within 48 hr following exposure to the infecting microorganism. Although a depression of PBI persisted throughout the period of observation in the vaccinated group,...
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