Abstract
The peripheral venous plasma concentrations of pregnenolone (Δ5-P), 17-hydroxypregnenolone (Δ5-17-OHP), progesterone (P), 17-hydroxyprogesterone (17-OHP), and cortisol were measured in 5 normal men during a 3-hour infusion of ACTH. The concentrations of Δ5-P, Δ5-17-OHP reached levels 4 to 6 times those of control samples, whereas progesterone, 17-OHP, and cortisol concentrations had only doubled. We propose that ACTH causes preferential stimulation of the Δ5 pathway for cortisol biosynthesis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: The Journal of Clinical Endocrinology & Metabolism
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
