Early adiposity rebound: prevalence and the effect on metabolic risk in children

Abstract

The timing of the adiposity rebound (AR) gradually shifted to earlier ages throughout the world; early AR has a great effect on children's health, especially is possible associated with the development of metabolic disease for life, while the special mechanism isn't very clear. Metabolic diseases(MD) are common in adults, and the establishment of MD is the result of pathological chronic processes that can start in early life stages. If the metabolic risk factors and its predictive factors can be found in early childhood, it can bring forward the prevention and control of adult diseases. This paper is a review of the prevalence of early AR around the world, the factors that influence the timing of the AR, the significance of early detection and prevention of MD, the associations between timing of AR and metabolic risk in children and explored the possible mechanism. It aims to raise public awareness about the harm of early AR and provide new perspective to prevent and control of the metabolic syndrome.