Eagle-i: An Ontology-Driven Framework For Biomedical Resource Curation And Discovery

Abstract

AbstractThe eagle-i Consortium ("http://www.eagle-i.org/home":www.eagle-i.org/home) comprises nine geographically and ethnically diverse universities across America working to build a federated network of research resources. Biomedical research generates many resources that are rarely shared or published, including: reagents, protocols, instruments, expertise, organisms, training opportunities, software, human studies, and biological specimens. The goal of eagle-i is to improve biomedical research by helping researchers more easily find scientific resources that are difficult to discover, reducing time-consuming and expensive duplication of resources. Now in early development, the system will ultimately expand to include research resources at other universities following the end of the two-year pilot phase. An application ontology is being developed to enable representation of core facility and research lab resources in the eagle-i repository, leading to more effective searches and better linkage between data types. The eagle-i ontology will guide users to valid queries via auto-suggestion, ontology browsing, concept-based search, and synonym expansion. The ontology development effort is being guided by active discussions within the ontology community and brings together relevant preexisting ontologies in a logical framework. Components of the data entry and search interfaces are generated directly from the ontology, which allows rapid change in response to user needs and ontology evolution. Each eagle-i institution will populate and manage a local repository using data collection and curation tools. To enhance the quantity and quality of data, the data tools will take advantage of the ontology to support semi-automated annotation of resources. NIH/NCRR ARRA award U24RR029825.