E44 Differences of hematological abnormalities between COVID-19 infection and multisystemic inflammatory syndrome (MIS-C)

Abstract

Abstract Introduction SARS-CoV-2 virus was associated with hypercoagulability and hematological abnormalities. Objectives We aim to compare hematological findings in acute COVID-19 and MIS-C syndrome. Methods This was a retrospective cohort study conducted for one year (March 2020 to March 2021) in the isolation unit of the children’s hospital. Children with confirmed COVID-19 infection and those who met the criteria for MIS-C by the World Health Organization definition were included. Laboratory results were collected through patients ‘files. Results We enrolled 99 children in our case series. Sixty-seven (68%) had COVID-19 infection (median age: 3.8 years) and 32 (32%) had MIS-C syndrome (median age: 7.5 years). Sex ratio was 1.8 (64 boys’ vs 35 girls). In COVID-19 infection, 24 patients (35.8%) had anaemia (median value: 11 g/dl). Leucocytosis was found in 13 cases (19.4%) (median value: 18 187/mm3, range: 6540–86 250) vs leucopenia in two cases. Lymphopenia was detected in 22 (32.8%) (median value: 1317 109/l, range: 800–3500). In MIS-C syndrome cohort, anaemia was detected in 20 (62.5%) with a median value of 10.8 g/dl (range : 6–12.8). Leucocytosis and leukopenia were in 7 (21.9%) and 1 (3.1%) cases respectively (median value: 20 650 cells/ml vs 3620 cells/ml). Lymphopenia was marked in 24 (75%) (median value : 896x109/l) and thrombocytopenia was present in 10 (31.3%) (median value : 125 200 cells/ml). Raised level of D-dimers was found in 21 (65.6%, range: 500-20 780 ng/ml) but no one had thrombosis. Conclusions Anaemia, lymphopenia and hypercoagulopathy were more related to MIS-C syndrome rather to acute COVID-19 form. Ethics no conflicts of interest