Abstract
Multiple myeloma (MM) cells are hypersensitive to proteasome inhibitors, indicating that aberrant ubiquitin signaling may have an important role in its pathogenesis. Here, we investigated translational role of ubiquitin signaling in MM and show that the E2 ubiquitin conjugase, UBE2T, is frequently amplified and highly expressed in MM cells, and its elevated expression as well as copy number correlate with poor patient survival. UBE2T is involved in genome maintenance via the Fanconi Anemia pathway.
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