(E)-1-(benzo [d] [1,3] dioxol-5-yl)-3-phenyl prop‑2-en-1-ones: Design, synthesis, anti-cancer activity and molecular docking studies

Abstract

The six derivatives of (E)-1-(benzo [d] [1,3] dioxol-5-yl)-3-phenyl prop‑2-en-1-ones (1a-1f) have been designed, synthesized, characterized and evaluated for preliminary biological activity using drug docking studies. The structure activity relationship (SAR) results have shown the compounds with different activites. The highest activity of compound 1e is found from its docking score by molecular docking results. The in vitro anticancer experimental results and structure activity relationship studies were supported using molecular docking studies on these novel hybrids.