E1A as a tumor suppressor gene: commentary re S. Madhusudan et al. A multicenter Phase I gene therapy clinical trial involving intraperitoneal administration of E1A-lipid complex in patients with recurrent epithelial ovarian cancer overexpressing HER-2/neu oncogene.

Abstract

Adenovirus E1a protein presents an interesting paradox. When expressed in primary rodent cells, E1a facilitates oncogenic transformation by activated ras or an activator of c-src signaling, polyoma middle T protein [(1)][1] . However, adenovirus E1a is nononcogenic in human cells: adenovirus