E-145 Safety of pediatric cerebral angiography

Abstract

<h3>Introduction/Purpose</h3> Catheter-based cerebral angiography is commonly used for neurovascular diagnosis in children. In this work, we aim to quantify the complication rate of cerebral angiography in children, characterize these complications, and identify risk factors for complications. <h3>Materials and Methods</h3> Relevant clinical data were retrospectively obtained for 587 consecutive cerebral angiography procedures performed in 390 children from March 2002 to March 2020. Complications were categorized as neurologic or non-neurologic, and severity was graded using a standard schema. Incidences of complications are reported as point estimates. Associations between risk factors and complications were characterized in univariate analysis using the two-tailed Fisher exact test and in multivariate analysis using multiple logistic regression with bidirectional elimination based on the Akaike information criterion. In both univariate and multivariate analyses, statistical significance was corrected for multiple comparisons using the Benjamini-Hochberg method with a prespecified false discovery rate of 0.05. <h3>Results</h3> Complications occurred in 6.5% of procedures, including 1.9% neurological complications and 4.8% non-neurological complications. Permanent deficits occurred in only 0.2% of cases, corresponding to a single thromboembolic event. Overall, 0.5% of procedures resulted in major complications while 6.0% resulted in minor complications. Access site complications occurred in 0.7% of procedures and technical complications occurred in 0.3% of procedures. History of hypertension, history of ischemic stroke, and female sex were associated with an increased risk of complications, while femoral artery access was associated with a decreased risk of complications. <h3>Conclusions</h3> Pediatric cerebral angiography has a low rate of major or permanent complications. Children with history of hypertension, history of ischemic stroke, or female sex are at higher risk of complications, while use of femoral access carries lower risk of complications. <h3>Disclosures</h3> <b>D. Lauzier:</b> None. <b>J. Osbun:</b> 2; C; Medtronic, Microvention. <b>A. Chatterjee:</b> None. <b>C. Moran:</b> 2; C; Medtronic, Cerenovus. <b>A. Kansagra:</b> 2; C; Penumbra, Microvention, iSchemaView.