Abstract
Backgrounds Home blood pressure (HBP) measurement has been found to have a stronger relationship with target organ damage. Recent studies have explored the association between variabilities of BP and target organ damage. Therefore, we investigated the relationship between day-by-day variabilities of HBP and diabetic nephropathy in Japanese patients with type 2 diabetes. Methods We compared the coefficient variation (CV) of HBP in 858 Japanese patients withand withoutmacroalbuminuria. Next, we analyzed the relationship between logarithm of urinary albumin excretion and the CV of HBP using linear regression analysis. Then, we evaluated the association of the CV of HBP with macroalbuminuria using logistic regression analysis. Results The CV of morning systolic blood pressure in patients with macroalbuminuria was significantly greater than that without (8.08 ± 3.35% vs. 7.19 ± 2.25%, p < 0.05). Multivariate linear regression analyses indicated that CV of morning systolic (P < 0.05) was the independent explanatory variables for logarithm of urinary albumin excretion. Multivariate logistic regression analysis demonstrated that the odds ratio of the CV of morning systolic blood pressure for macroalbuminuria was 1.35 (P < 0.05). Conclusions The CV of HBP correlated with macroalbuminuria independent of the known risk factors in Japanese patients with type 2 diabetes.
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